17 Most Used Cryptocurrencies in the USA

As we move deeper into 2025, it’s clear that the U.S. isn’t just watching the global crypto revolution, it's actively leading it. From tech-forward cities like Austin and Miami to Silicon Valley venture capital circles, digital assets are redefining finance, identity, and ownership. 

According to May 2025 data from CoinGecko, Americans are showing strong engagement with a diverse set of cryptocurrencies, ranging from blue-chip leaders to culture-infused meme tokens.

This list breaks down the 17 most used cryptocurrencies in the United States, offering insight into what Americans are trading, holding, and using every day.

Top 17 Most Used Cryptocurrencies in the USA (May 2025)

Note: The ranking is based on U.S. user engagement metrics as reported by CoinGecko’s May 2025 data.

Read Also: Why is Bitcoin (BTC) Price Going Up? Exploring the Trigger Factor

What Makes These Cryptos Popular in the USA?

These tokens reflect more than just price action; they represent narratives, innovations, and behavioral trends across U.S. users. Let’s explore what’s driving usage:

1. Institutional Confidence Meets Retail Demand

Bitcoin and Ethereum remain at the heart of institutional portfolios thanks to the rise of Bitcoin ETFs, Ethereum staking derivatives, and their role in multi-chain DeFi ecosystems.

However, retail traders are leaning toward a blend of legacy and novelty. Platforms like Robinhood, Coinbase, and Kraken offer easy access to both stable giants like BTC and ETH and newer, more volatile tokens like GASS, PEPE, and TRUMP.

2. Culture-Driven Coins

Tokens like Pepe (PEPE), Dogecoin (DOGE), and Shiba Inu (SHIB) carry meme momentum. They thrive in American digital subcultures, leveraging humor, irony, and virality.

Likewise, Official Trump (TRUMP) isn’t just politically charged its proof that identity and belief systems are becoming tokenized.

3. Utility and Next-Gen Infrastructure

Projects like Sui, Zebec, and Hyperliquid offer clear utility.

• Sui provides lightning-fast transaction finality for Web3 apps.
  
   

• Zebec allows real-time payroll in crypto, a huge innovation for freelancers and startups.
  
   

• Hyperliquid is emerging as a decentralized derivatives powerhouse, pulling U.S. users from traditional platforms.

Read Also: Will SOL Go Up Higher Again? Bullish Momentum Continues

Crypto Adoption Trends in the USA – 2025 Insights

Crypto Ownership Is Mainstream

Surveys suggest nearly 28% of U.S. adults now own crypto, doubling from 2021. This surge is driven by:

• Better onboarding UX on exchanges and wallets
  
   

• Mobile-first DeFi platforms
  
   

• Rising distrust in traditional finance

Whether it’s staking SOL, farming SUI, or simply holding BTC on a Ledger wallet, crypto has gone from speculative to foundational.

Read Also: Can SHIB Make You Rich Again? Looking at the 10X Potential

Politics and Crypto Now Intersect

2024's U.S. election cycle amplified the role of crypto in political discourse. From presidential candidates supporting Bitcoin mining to bills favoring stablecoin regulation, the U.S. crypto community is more politically active than ever.

Tokens like TRUMP reflect this synergy serving as both speculative assets and ideological tokens.

Cross-Chain and AI Integration

U.S.-based projects are also spearheading innovations where AI meets crypto, and cross-chain interoperability becomes standard. Wallets now support seamless swaps between ecosystems like Ethereum, Solana, and Cosmos reducing friction and increasing user time on-chain.

Final Thoughts

The list of the 17 most used cryptocurrencies in the USA reveals more than transactional preferences; it reflects how Americans engage with emerging digital economies. Whether driven by ideology, innovation, or entertainment, crypto has rooted itself in U.S. culture, economy, and daily behavior.

As infrastructure strengthens and narratives evolve, this list will transform—but crypto’s role in shaping the future of American finance is already locked in.

Read Also: SHIB Rises As Bullish Momentum Continues! Can the Memecoin Market Hold Steady?

FAQ

Q: What is the most used cryptocurrency in the United States in 2025?
A: According to May 2025 data from CoinGecko, iMe Lab (LIME) ranks as the most used crypto by U.S. users, followed by Gasspas (GASS) and Bitcoin (BTC). Usage is based on traffic, wallet interactions, and trading volumes.

Q: Why are meme coins like PEPE and DOGE still popular in the USA?
A: Meme coins tap into American internet culture, humor, and community building. They're often used for social engagement and speculative trading, driven by platforms like X (formerly Twitter), Reddit, and TikTok.

Q: Is crypto legal and regulated in the U.S.?
A: Yes, but regulation varies. Bitcoin and Ethereum are widely accepted, while stablecoins and newer tokens may face scrutiny. The SEC and CFTC are working to clarify classification rules, especially after the approval of Bitcoin ETFs.

Q: Are Americans using crypto beyond investing?
A: Absolutely. U.S. users are leveraging crypto for payroll (ZBCN), tipping, donations, NFT gaming, and even political participation (TRUMP token). There's also increasing usage in DeFi and AI-integrated finance apps.

Q: Which platform is best for U.S. users to buy crypto?
A: Popular choices include Coinbase, Kraken, Binance US, Robinhood, and decentralized platforms like Uniswap and Hyperliquid. Each offers different levels of compliance, coin variety, and fees.

Q: How is Solana (SOL) performing in the U.S. market?
A: Solana is thriving, ranking in the top 10 most used tokens. Its appeal comes from high-speed, low-cost transactions and growing app ecosystems, especially in gaming and decentralized infrastructure projects.

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